Michel Koole Selected Research

MK-6240

1/2020

Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles.

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Michel Koole Research Topics

Disease

9	Neuroinflammatory Diseases 08/2021 - 01/2016
7	Neoplasms (Cancer) 10/2021 - 08/2012
6	Alzheimer Disease (Alzheimer's Disease) 12/2022 - 08/2009
5	Parkinson Disease (Parkinson's Disease) 01/2020 - 01/2013
5	Schizophrenia (Dementia Praecox) 01/2017 - 01/2013
4	Inflammation (Inflammations) 08/2021 - 08/2013
3	Cognitive Dysfunction 10/2022 - 01/2021
3	Atrophy 01/2022 - 01/2018
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 12/2018
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2020 - 12/2018
2	Stroke (Strokes) 01/2022 - 11/2012
2	Central Nervous System Diseases (CNS Diseases) 10/2021 - 01/2014
2	Infections 01/2021 - 01/2018
2	Carcinoma (Carcinomatosis) 12/2017 - 08/2013
2	Myocardial Infarction 01/2015 - 01/2013
2	Amyloidosis 03/2014 - 08/2009
2	Obesity 01/2014 - 03/2008
2	Prostatic Neoplasms (Prostate Cancer) 04/2013 - 08/2012
1	Ischemic Stroke 01/2022
1	Chemotherapy-Related Cognitive Impairment 08/2021
1	Breast Neoplasms (Breast Cancer) 08/2021
1	Mental Disorders (Mental Disorder) 01/2021
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2021
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2020
1	Hemolysis 01/2020
1	Parkinsonian Disorders (Parkinsonism) 01/2020
1	Frontotemporal Dementia (Semantic Dementia) 01/2020
1	Hyperoxia 01/2019
1	Broca Aphasia (Expressive Aphasia) 12/2018
1	Tauopathies 12/2018
1	Primary Progressive Aphasia 12/2018
1	Communicable Diseases (Infectious Diseases) 01/2018
1	Hypercapnia 02/2017
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2017
1	Fragile X Syndrome (Martin Bell Syndrome) 12/2015
1	Atherosclerosis 12/2015
1	Atherosclerotic Plaque (Atheroma) 12/2015
1	Infarction (Infarctions) 08/2014
1	Heart Diseases (Heart Disease) 08/2014
1	Necrosis 03/2014
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2014

Drug/Important Bio-Agent (IBA)

7	Biomarkers (Surrogate Marker)IBA 10/2021 - 08/2009
6	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 04/2013
4	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 08/2021 - 01/2016
4	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2021 - 12/2018
3	Amyloid (Amyloid Fibrils)IBA 10/2022 - 01/2018
3	Proteins (Proteins, Gene)FDA Link 08/2021 - 01/2018
3	Purinergic P2X7 ReceptorsIBA 01/2020 - 01/2016
3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2017 - 01/2013
2	FluorineIBA 01/2021 - 01/2020
2	Radioisotopes (Radionuclides)IBA 01/2020 - 12/2017
2	LipopolysaccharidesIBA 12/2018 - 01/2016
2	salicylhydroxamic acid (SHAM)IBA 01/2015 - 11/2012
2	Cannabinoid Receptors (Cannabinoid Receptor)IBA 08/2013 - 11/2012
2	Choline (Choline Chloride)IBA 04/2013 - 08/2012
2	EndocannabinoidsIBA 11/2012 - 03/2008
1	Muscarinic M4 ReceptorIBA 12/2022
1	1- ((3- (methylpyridin- 4- yl)methyl)- 4- (3,4,5- trifluorophenyl)pyrrolidin- 2- oneIBA 01/2022
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/2021
1	Polyvinyl Chloride (PVC)IBA 01/2021
1	1,10- phenanthroline- platinum(II)- ethylenediamine (PEPT)IBA 01/2021
1	DOTA-Tyr(3)- 90Y-octreotideIBA 01/2020
1	Ga(III)-DOTATOCIBA 01/2020
1	MK-6240IBA 01/2020
1	Peptide Receptors (Peptide Receptor)IBA 01/2020
1	2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropaneIBA 01/2020
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2020
1	Ion Channels (Ion Channel)IBA 09/2019
1	Adenosine Triphosphate (ATP)IBA 09/2019
1	CannabinoidsIBA 01/2019
1	alpha-SynucleinIBA 01/2019
1	Surface-Active Agents (Surfactants)IBA 01/2019
1	THK5351IBA 12/2018
1	DNA-Binding Proteins (DNA Binding Protein)IBA 12/2018
1	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA 01/2018
1	Antimicrobial PeptidesIBA 01/2018
1	ribosomal protein S30IBA 01/2018
1	Peroxisomal Multifunctional Protein-2IBA 01/2018
1	AntibodiesIBA 12/2017
1	Fluorine-18IBA 12/2017
1	Trastuzumab (Herceptin)FDA Link 12/2017
1	ChloraloseIBA 02/2017
1	Urethane (Ethyl Carbamate)IBA 02/2017
1	metabotropic glutamate receptor 2IBA 01/2017
1	Metabotropic Glutamate 5 ReceptorIBA 12/2015
1	Arginine (L-Arginine)FDA Link 12/2015
1	Aspartic Acid (Aspartate)FDA Link 12/2015
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 12/2015
1	IntegrinsIBA 12/2015
1	Glycine Plasma Membrane Transport ProteinsIBA 01/2015
1	Prealbumin (Transthyretin)IBA 03/2014
1	Antineoplastic Agents (Antineoplastics)IBA 03/2014
1	hypericinIBA 03/2014
1	Ethanol (Ethyl Alcohol)IBA 01/2014

Therapy/Procedure

3	Therapeutics 01/2020 - 04/2013
2	Injections 01/2019 - 08/2014
1	Drug Therapy (Chemotherapy) 08/2021
1	Anesthesia 02/2017
1	Ligation 01/2015
1	Biological Therapy 08/2014